聚乳酸/羟基磷灰石晶须复合多孔支架的制备与性能研究

采用溶剂浇铸/真空挥发/粒子沥滤方法,采用氯化钠为造孔剂、氯仿为溶剂,最终制备出聚乳酸(PLA)/羟基磷灰石晶须(HAw)复合多孔支架.通过SEM表征了聚乳酸支架的表面形貌,用XRD、SEM、FT-IR等分析了加入不同量HAw的聚乳酸的成分、形貌以及结构特征,并研究羟基磷灰石晶须的添加量对支架的孔洞结构参数、力学性能及生物性能的影响,结果表明:可以通过控制氯化钠的粒度及用量来调节支架的孔径及孔隙率;聚乳酸(PLA)/羟基磷灰石晶须(HAw)复合多孔支架结构均匀,具有较高的孔隙率和良好的孔隙连通性;支架孔隙率在83.94;～91.08;范围内,可以满足骨组织工程对支架材料的要求;复合多孔支架的抗压强度达到5.72～ 12.73 MPa,在羟基磷灰石晶须质量比为10;时达到最大值,为12.73 MPa.

Fabrication and Properties of Poly/Hydroxyapatite Whisker with Composite Porous Scaffolds

The polylactic acid (PLA) and polylactic acid/hydroxyapatite whisker (HAw) composite porous scaffolds were fabricated through the solvent casting/vacuum evaporation/particle leaching method,using the sodium chloride as pore former,the chloroform as solvent.The surface morphology of polylactic acid are characterized by the SEM photographs.The XRD,SEM and Fr-IR,etc are employed to examine the composite morphology and structure characteristics of the polylactic acid with different quantity of HAw.Besides,we study the effect of the hydroxyapatite whisker contents on the hole structure parameters,mechanical properties and biological performance of the scaffolds material.The results reveal that the pore size and porosity of the scaffold can be controlled by the size and amount of the sodium chloride.The PLA/HAw series show the uniform structure,high porosity and good pore connectivity.The porosity of PLA/HAw composite porous scaffold ranges from 83.94％ to 91.08％,which could meet the requirements of scaffolds for bone tissue engineering.The compressive strength of composite porous scaffolds is 5.72-12.73 MPa.Furthermore,the compressive strength reaches the maximum value of 12.73 MPa in 10％ HAw/PLA.