Surface Treatment of Dimenhydrinate Crystals |
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Authors: | Bajdik J Pintye-Hódi K Novák Cs Szabó-Révész P Regdon G Er?s I Pokol G |
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Institution: | 1.Department of Pharmaceutical Technology, University of Szeged, E?tv?s u. 6, H-6720, Szeged, Hungary ;2.Institute of General and Analytical Chemistry, Budapest University of Technology and Economics and Research Group for Technical Analytical Chemistry of the Hungarian Academy of Sciences, Szent Gellért tér 4, H-1111 Budapest, Hungary ; |
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Abstract: | Dimenhydrinate is a heat-sensitive antihistamine with a low melting point. The heat-sensitive feature is of importance if
direct compression is used. Direct measurement of the heat originating in the texture of tablets during compression is very
difficult. Thermoanalytical methods were used as indirect methods to describe the changes in material properties at high temperature:
differential scanning calorimetry, thermomicroscopy and thermogravimetric analysis. Film coating method is widely used in
pharmaceutical technology. A fluidized bed apparatus was applied to coat the crystals. The coating film forming agent was
hydroxy-propyl-methylcellulose (HPMC), which is a gastric-soluble polymer. Thermoanalytical measurements reveal that dimenhydrinate
crystals are sensitive to heat. Film coating method does not alter the shape of the DSC curve of dimenhydrinate, but increases
the melting point. The presence of a macromolecular film reduces the thermal conductivity, because it separates the particles.
This revised version was published online in August 2006 with corrections to the Cover Date. |
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Keywords: | dimenhydrinate DSC film coating HPMC thermal conductivity |
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