Signalling crosstalk in FGF2-mediated protection of endothelial cells from HIV-gp120 |
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| Authors: | Email author" target="_blank">Dianne?LangfordEmail author Rosemary?Hurford Makoto?Hashimoto Murat?Digicaylioglu Eliezer?Masliah |
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| Institution: | (1) Department of Pathology, University of California, San Diego, La Jolla, CA, USA;(2) Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA;(3) The Burnham Institute Center for Neuroscience and Aging, La Jolla, CA, USA |
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| Abstract: | Background The blood brain barrier (BBB) is the first line of defence of the central nervous system (CNS) against circulating pathogens,
such as HIV. The cytotoxic HIV protein, gp120, damages endothelial cells of the BBB, thereby compromising its integrity, which
may lead to migration of HIV-infected cells into the brain. Fibroblast growth factor 2 (FGF2), produced primarily by astrocytes,
promotes endothelial cell fitness and angiogenesis. We hypothesized that treatment of human umbilical vein endothelial cells
(HUVEC) with FGF2 would protect the cells from gp120-mediated toxicity via endothelial cell survival signalling. |
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