Oxidative cleavage of alkenes using an in situ generated iodonium ion with oxone as a terminal oxidant |
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Authors: | Thottumkara Prem P Vinod Thottumkara K |
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Affiliation: | Department of Chemistry, Western Illinois University, Macomb, Illinois 61455, USA. |
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Abstract: | A facile and operationally convenient catalytic procedure for oxidative cleavage of alkenes is described. In situ formed [hydroxy(4-carboxyphenyl)iodonium]ion, 2, from the oxidation of 4-iodobenzoic acid, 1, has been shown to facilitate the cleavage of a variety of alkenes in presence of Oxone as a co-oxidant. Optimization of the reaction conditions using 1-phenyl-1-cyclohexene, 3, and the competitive oxidative cleavage of different substrates using the optimized conditions has uncovered important mechanistic details of the reaction. |
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