Iridium‐Catalyzed Coupling Reaction of Primary Alcohols with 2‐Alkynes Leading to Hydroacylation Products |
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| Authors: | Shintaro Hatanaka Yasushi Obora Dr. Yasutaka Ishii Prof. Dr. |
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| Affiliation: | Department of Chemistry and Material Engineering, Faculty of Chemistry, Materials and Bioengineering, High Technology Research Center, and ORDIST, Kansai University, Suita, Osaka 564‐8680 (Japan), Fax: (+81)?6‐6339‐4026 |
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| Abstract: | A novel iridium‐catalyzed intermolecular coupling reaction of primary alcohols or aldehydes with 2‐alkynes was successfully achieved with high regioselectivity to give hydroacylation products such as α,β‐unsaturated ketones in good yields. The mechanistic investigation of the reaction strongly indicated that the coupling proceeds through the initial formation of homoallylic alcohols followed by dehydrogenation to β,γ‐unsatutated ketones and then isomerisation, which leads to the hydroacylation products. |
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| Keywords: | alcohols aldehydes alkynes hydroacylation iridium |
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