Selective targeting of DNA for cleavage within DNA-histone assemblies by a spermine-[CpW(CO)3Ph]2 conjugate |
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| Authors: | Shell Thomas A Mohler Debra L |
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| Affiliation: | Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, GA 30322, USA. |
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| Abstract: | In contrast to the histone-modifying action of other complexes of the type CpML(n)R, the compound obtained by linking the phenyl rings of two CpW(CO)(3)Ph moieties to the DNA-binding agent spermine selectively cleaves DNA in DNA-histone assemblies. |
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