5-Arylmethylene-2,4-imidazolidinediones and 5-arylmethylene-2-thioxo-4-imidazolidinones derivatives: stereochemistry elucidation by H and C NMR期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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5-Arylmethylene-2,4-imidazolidinediones and 5-arylmethylene-2-thioxo-4-imidazolidinones derivatives: stereochemistry elucidation by H and C NMR

Authors:	Patrick Fresneau Jean-Marc Morand Franois Thomasson Max Cussac

Institution:	^a Laboratoire de Chimie Thérapeutique, Groupe de Pharmacochimie Moléculaire, CNRS-EP811, Université Joseph Fourier, UFR de Pharmacie, Domaine de la Merci, 38700 La Tronche, France;^b Service Commun de RMN, Groupe de Pharmacochimie Moléculaire, CNRS-EP811, Université Joseph Fourier, UFR de Pharmacie, Domaine de la Merci, 38700 La Tronche, France

Abstract:	Derivatives of 5-arylmethylene-2,4-imidazolidinediones and 5-arylmethylene-2-thioxo-4-imidazolidinones were synthesized as potential aldose reductase inhibitors (ARI). The Z/E configuration was elucidated by homonuclear NOE difference spectra and by proton-carbon coupling constant measurement from ¹³C coupled spectra using GATEDEC and SFDEC programs.

Keywords:	NMR Homonuclear NOE C– H Coupling constants 5-Arylmethylene-2 4-imidazolidinediones 5-Arylmethylene-2-thioxo-4-imidazolidinones Aldose reductase inhibitors (ARI)
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