Synthesis, quality control and biodistribution of 99mTc-Kanamycin |
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| Authors: | S. Roohi A. Mushtaq M. Jehangir S. A. Malik |
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| Affiliation: | (1) Isotope Production Division, Pakistan Institute of Nuclear Science and Technology, P.O. Nilore, Islamabad, Pakistan;(2) Isotope Production Division, Pakistan Institute of Nuclear Science and Technology, P.O. Nilore, Islamabad, Pakistan;(3) Isotope Production Division, Pakistan Institute of Nuclear Science and Technology, P.O. Nilore, Islamabad, Pakistan;(4) Department of Biological Sciences, Quaid-e-Azam University, Islamabad, Pakistan |
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| Abstract: | Summary Kanamycin is an antibiotic used for treatment of infections when penicillin or other less toxic drugs cannot be used. Kanamycin was labeled with technetium-99m pertechnetate using SnCl2. 2H2O as reducing agent. The labeling efficiency depends on the ligand/reductant ratio, pH, and volume of reaction mixture. Radiochemical purity and stability of 99mTc-Kanamycin was determined by thin layer chromatography. Biodistribution studies of 99mTc-Kanamycin were performed in rats and rabbits. A significantly higher accumulation of 99mTc-Kanamycin was seen at sites of S. aureusinfected animals (rat/rabbit). |
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