Cell migration rate on poly(epsilon-caprolactone)/poly(ethylene glycol) diblock copolymers and correlation with the material sliding angle |
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Authors: | Hsu Shan-hui Tang Cheng-Ming Chiu Jeng-Jiann Liao Tien-Chi Lin Chu-Chieh Iwata Hiroo |
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Institution: | Center of Tissue Engineering and Stem Cells Research, National Chung Hsing University, Taichung, Taiwan, Republic of China. shhsu@nchu.edu.tw |
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Abstract: | The nanostructure of a biomaterial surface has strong influence on cell behavior. The migration of cells on nanostructured surfaces, however, has not been investigated so far. In this study, we used PCL/PEG diblock copolymers as model surfaces to examine the effect of nanoislands on migration of different cells, including fibroblasts and endothelial cells. The water sliding angle of the substrates was measured. The cell migration rate was examined under a real-time optical microscope. It was found that a greater cell migration rate correlated with the smaller sliding angle of the substrate. |
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Keywords: | cell migration microphase separation nanotopography PCL/PEG diblock copolymer sliding angle |
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