Synthesis and characterization of polyester dendrimers from acetoacetate and acrylate |
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| Authors: | Hirayama Yuuki Nakamura Taisuke Uehara Satoshi Sakamoto Yohko Yamaguchi Kentaro Sei Yoshihisa Iwamura Michiko |
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| Institution: | Department of Biomolecular Science and School of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan. |
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| Abstract: | New aliphatic polyester-type dendrimers were synthesized using a new AB2-type building block 3, prepared from benzyl acetoacetate and 2 equiv of tert-butyl acrylate by acetoacetic acid ester synthesis. The reiterative deprotection by HCO2H, then EDCI/DMAP coupling] sequence using divergent growth method gave G1]-4tBu-G5]-64tBu dendrimers. 13C NMR relaxation time (T1) measurements on the carboxy carbons show that the extended chain conformations are predominant in CDCl3. structure: see text] |
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