| Synthesis and Bioactivity of Isosteviol Derivatives： A Facile Method for Preparation of Ent-16α-hydroxy-15β-hydroxymethylbeyeran-19-oic Acid |
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| 作者姓名： | Jing Chao TAO Guo Qiang TIAN Yan Bing ZHANG Yu Qin FU Gui Fu DAI Ya WU |
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| 作者单位： | Department of Chemistry, Zhengzhou University, Zhengzhou 450052 |
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| 基金项目： | We are grateful to the National Natural Science Foundation of China （20372059） and Natural Science Foundation of Henan Province for the financial support （0311020500）. |
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| 摘 要： | In this paper, two new compounds, ent-16α-hydroxy-15β-hydroxymethylbeyeran-19-oic acid 4 and its ethyl ester 5 were synthesized in good yield with a facile method that has never been reported. The mechanism of this reaction was discussed and the mono-hydroxymethylation of carbonyl compound with two α-hydrogens via Tollens＇ reaction was firstly achieved. Compounds 2-5 were tested for activity of inhibition against glycosidases, among which 5 displays good inhibition of β-glucosidase and α-mannase, respectively.
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| 关 键 词： | 二醇 合成方法 生物活性 衍生物 |
| 收稿时间： | 2005-01-31 |
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