Jacobsen-type enantioselective hydrolysis of aryl glycidyl ethers. 31P NMR analysis of the enantiomeric composition of oxiranes期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Jacobsen-type enantioselective hydrolysis of aryl glycidyl ethers. 31P NMR analysis of the enantiomeric composition of oxiranes

Authors:	Bredikhin A A Strunskaya E I Novikova V G Azancheev N M Sharafutdinova D R Bredikhina Z A

Institution:	(1) A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences, 8 ul. Akad. Arbuzova, 420088 Kazan, Russian Federation

Abstract:	The enantioselective partial hydrolysis of a number of racemic aryl glycidyl ethers in the presence of chiral Co(salen)-catalyst was studied. The enantiomeric composition of the isolated (R)-aryl glycidyl ethers was analyzed by ³¹P NMR using optically active substituted 2-chloro-1,3,2-dioxaphospholanes. A synthesis of -adrenoblocking agents (S)-toliprolol and (S)-moprolol based on the simultaneously obtained (S)-3-aryloxypropane-1,2-diols was proposed.

Keywords:	enantioselective hydrolysis chiral Co(salen)-catalyst aryl glycidyl ethers enantiomeric purity ³¹P NMR 3-aryloxypropane-1 2-diols toliprolol moprolol
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