Microbial transformation of (+)-adrenosterone |
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| Authors: | Musharraf S Ghulam Atta-Ur-Rahman Choudhary M Iqbal Sultan Sadia |
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| Institution: | H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Pakistan. |
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| Abstract: | The microbial transformation of (+)-adrenosterone (1) by Cephalosporium aphidicola afforded three metabolites identified as androsta-1,4-diene-3,11,17-trione (2), 17beta-hydroxyandrost-4-ene-3,11-dione (3) and 17beta-hydroxyandrosta-1,4-diene-3,11-dione (4). The fermentation of 1 with Fusarium lini also produced metabolites 2 and 4, while the fermentation with Trichothecium roseum afforded metabolite 3. The structures of transformed products were determined by spectroscopic methods. |
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