Theoretical features of macrocyclization equilibria and their application on transacetalation based dynamic libraries |
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Authors: | Stefano Di Stefano |
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Affiliation: | Sapienza Università di Roma and IMC‐CNR Sezione Meccanismi di Reazione Dipartimento di Chimica, Italy |
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Abstract: | The theoretical treatment of macrocyclization reactions under thermodynamic control is overviewed in the light of recent growing interest toward Dynamic Combinatorial Chemistry (DCC). The rules governing the equilibrium processes in Dynamic Library (DL) under conditions of perfect mass balance are illustrated. Data related to transacetalation reactions of cyclophane formaldehyde acetals are thoroughly discussed as remarkable examples of systems where experiments and theory make a good match. Copyright © 2010 John Wiley & Sons, Ltd. |
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Keywords: | dynamic combinatorial chemistry effective molarity Jacobsen– Stockmayer theory macrocyclization equilibria thermodynamic control |
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