Bioresponsive nanogated ensemble based on structure-switchable aptamer directed assembly and disassembly of gold nanoparticles from mesoporous silica supports |
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Authors: | Zhiyong Zhang A. Runa Jie Wu Han Zhang Xia Li Zhiqiang He |
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Affiliation: | Inner Mongolia Power Research Institute, Hohhot 010020, China |
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Abstract: | By taking advantage of recent advances in aptamer biology and nanotechnology, we developed a general approach for the design and fabrication of bioresponsive controlled delivery systems. It utilized the structure-switchable aptamer directed assembly and disassembly of gold nanoparticles from mesoporous silica supports, which enables the control of cargo release from the inside of the mesoporous nanoparticles specifically in the presence of target molecule. |
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Keywords: | Mesoporous silica DNA aptamer Controlled release Bioresponsive Nanoparticle assembly |
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