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Ligand-free nickel-catalyzed Kumada couplings of aryl bromides with tert-butyl Grignard reagents
Authors:Zhenghan Wu  Tengda Si  Guangqing Xu  Bin Xu  Wenjun Tang
Affiliation:Department of Chemistry, Shanghai University, Shanghai 200444, China; State Key Laboratory of Bio-Organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Abstract:A ligand-free nickel-catalyzed Kumada cross-coupling of aryl bromides and tert-butyl Grignard reagents led to the formation of a series of tert-butyl aryls in moderate to good yields, excellent tBu/iBu ratios, and good functional group compatibility. A radical coupling process is indicated and a mechanism with a Ni(I)-Ni(III) catalytic cycle is proposed.
Keywords:Ligand free  Kumada cross-coupling  Nickel catalysis
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