Photo-induced synthesis and in vitro biological activity of a Sansalvamide A analog |
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| Authors: | Lishuang Zhao Hongyue Zhang Guanghui Tan Zhiqiang Wang Yingxue Jin |
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| Affiliation: | 1. College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, China;2. Key Laboratory of Molecular Cytogenetics and Genetic Breeding of Heilongjiang Province, Harbin Normal University, 150025 Harbin, China |
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| Abstract: | Photoinduced single electron transfer (SET) cyclization processes for synthesis of a Sansalvamide A analog containing double pharmacophores (cyclicpeptides and O-phthalimide moiety) is described to develop novel antitumor cyclopeptide drug. The resultant compound is active in drug-sensitive HeLa, HepG-2 and MCF-7 cell lines. Specifically, the title compound was found to inhibit MCF-7 cells with an IC50 value of 15 μM (13.4 μg/mL), which may serve as a potential candidate for antitumor drug development. |
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| Keywords: | Sansalvamide A Synthesis SET Cyclopeptide Bioactivity |
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