Micelles and reverse micelles with a photo and thermo double‐responsive block copolymer |
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| Authors: | Qiao Jin Gongyan Liu Jian Ji |
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| Institution: | Department of Polymer Science, Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Zhejiang University, Hangzhou 310027, China |
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| Abstract: | A novel photo and thermo double‐responsive block copolymer was developed to fabricate micelles and reverse micelles in aqueous solution. The block copolymer was synthesized by ATRP block copolymerization of a spiropyran‐ containing methacrylate (SPMA) with di(ethylene glycol) methyl ether methacrylate (DEGMMA). By facile control of the photo irradiation and solution temperature, PSPMA‐core and PDEGMMA‐core micelles can be obtained, respectively. The thermo‐ and photo‐responsive micelles were used as smart polymeric nanocarriers for controlled encapsulation, triggered release, and re‐encapsulation of model drug coumarin 102. The double‐responsive self‐assembly and disassembly were tracked by dynamic light scattering, transmission electron microscopy, and fluorescence spectroscopy. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 2855–2861, 2010 |
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| Keywords: | block copolymers micelle microencapsulation nanocarrier nanoparticles photo responsive reverse micelle stimuli‐sensitive polymers |
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