A general method for making bicyclic compounds with nitrogen at a bridgehead--application to the halichlorine spiro subunit |
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| Authors: | Clive Derrick L J Yu Maolin Li Zhiyong |
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| Affiliation: | Chemistry Department, University of Alberta, Edmonton, Alberta, Canada T6G 2G2. derrick.clive@ualberta.ca. |
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| Abstract: | N-protected beta-amino aldehydes having the nitrogen in a ring are easily converted into Morita-Baylis-Hillman adducts; O-acetylation and N-deprotection result in spontaneous cyclization to bicyclic structures having nitrogen at a bridgehead. |
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