微流控分析芯片的两种液相传质模式及其应用*

微流控分析芯片的微米级结构不仅显著增大内部流体的比界面积，同时缩短微通道内不同溶液间的传质距离，使传质效率相比于宏观体系有显著提高，从而可实现试样分析检测前的高效扩散分离和萃取富集等。本文综述了微流控分析芯片中两种液相传质模式——互溶液相间扩散分离分析、不互溶液相间萃取分离分析的研究进展，讨论了上述传质模式在微芯片装置和功能的集成化方面的应用；并讨论了相关研究的难点和发展趋势。

Application of Two Kinds of Liquid-Phase Mass Transfer in Microfluidic Analytical Chip

Due to the micro scale of inner structure of microfluidic analytical chip, the fluid possesses of high specific surface area as well as small diffusion distance which remarkably improves mass transfer rate and enhances sample pretreatment efficiency, such as diffusion or extraction separation before determination. In this paper, the applications of two kinds of liquid-phase mass transfer between miscible phases or immiscible phases in microfluidic analytical chip are reviewed. Further microfabrication and integration based on liquid-phase mass transfer for more complex devices and wider range of functions are introduced. The difficulties in technique development and application tendency are also discussed.