Lipase-catalyzed kinetic resolution of aryltrimethylsilyl chiral alcohols |
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Authors: | Palmeira Dayvson J Abreu Juliana C Andrade Leandro H |
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Affiliation: | Institute of Chemistry, University of S?o Paulo, Av. Prof. Lineu Prestes, n°. 748, SP 05508-900, S?o Paulo, Brazil. dayvson.palmeira@gmail.com |
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Abstract: | Lipase-catalyzed kinetic resolution of aryltrimethylsilyl chiral alcohols through a transesterification reaction was studied. The optimal conditions found for the kinetic resolution of m- and p-aryltrimethylsilyl chiral alcohols, led to excellent results, high conversions (c = 50%), high enantiomeric ratios (E > 200) and enantiomeric excesses for the remaining (S)-alcohol and (R)-acetylated product (>99%). However, kinetic resolution of o-aryltrimethylsilyl chiral alcohols did not occur under the same conditions applied to the other isomers. |
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