Simple modeling of the physical sample dispersion process in rectangular meso (micro) channels with pressure-driven flows |
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Authors: | Mireia Baeza José Luis Montesinos Julián Alonso Jordi Bartrolí |
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Institution: | (1) Grup de Sensors i Biosensors, Departament de Química, Facultat de Ciències, Edifici C-Nord, Universitat Autònoma de Barcelona, 08193 Bellaterra (Cerdanyola del Vallès), Spain;(2) Departament d’Enginyeria Química, Escola Tècnica Superior d’Enginyeria, Universitat Autònoma de Barcelona, 08193 Bellaterra (Cerdanyola del Vallès), Spain |
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Abstract: | The present paper reports the modeling and characterization of the physical sample dispersion process observed in rectangular
microchannels when pressure-driven pumping is used. To explain experimental results provided by the silicon fluidic device
constructed, two different mathematical models were tested. The first one is based on the diffusion–convection model, and
the second one is based on the combination of ideal reactors. The silicon designed and constructed chip includes a microfluidic
manifold with four inlet–outlet ports and a monolithically integrated optical flow cell. The microchannels, the optical flow
cell, and the input–output ports were micromachined on a silicon wafer and then sealed with Pyrex glass anodically bonded.
Optical windows were integrated in the chip, allowing simple absorbance–transmission measurements. Pressure-driven flows through
fluidic channels were controlled via three-way solenoid valves and provided by an automatic microburette operating in aspiration
mode. Experimentally obtained results demonstrate that the physical sample dispersion process can be easily modeled as a combination
of a continuous stirred tank reactor and a plug-flow reactor. |
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Keywords: | Hybrid system μ FIA Modeling Mixing Diffusion– convection CSTR PFR |
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