| 黄体酮的合成工艺改进 |
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| 引用本文： | 吴庆安,徐志超,柏挺.黄体酮的合成工艺改进[J].合成化学,2016,24(2):174-177. |
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| 作者姓名： | 吴庆安 徐志超 柏挺 |
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| 作者单位： | 1. 浙江工业大学 化学工程学院，浙江 杭州 310014; 2. 上海新华联制药有限公司，上海 201419 |
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| 摘 要： | 以植物甾醇为原料，分离得豆甾醇(1)； 1经沃氏氧化和臭氧化制得中间体孕甾-4-烯-3-酮-22-醛(3)； 3经加成缩合并在CuCl催化下经空气氧化合成了黄体酮，总产率69.1%，其结构经1H NMR和ESI-MS确证。
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| 关 键 词： | 植物甾醇 黄体酮 氧化 药物合成 工艺改进 |
| 收稿时间： | 2015-01-28 |
Process Improvement on the Synthesis of Progesterone |
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| WU Qing-an,XU Zhi-chao,BAI Ting.Process Improvement on the Synthesis of Progesterone[J].Chinese Journal of Synthetic Chemistry,2016,24(2):174-177. |
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| Authors: | WU Qing-an XU Zhi-chao BAI Ting |
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| Institution: | 1. College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China; 2. Shanghai New Hualian Pharmaceutical Co. Ltd., Shanghai 201419, China |
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| Abstract: | Stigmasterol(1) was separated from phytosterol. The intermediate, 3-ketobisnor-4-cholenaldehyde(3) was prepared through oppenauer oxidation and ozonation from 1. Progesterone was synthesized by addition-condensation and oxygenation catalyzed by cuprous chloride from 3. The overall yield was 69.1%. The structure was confirmed by 1H NMR and ESI-MS. |
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| Keywords: | phytosterol progesterone oxygenation drug synthesis process improvement |
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