4-(N-乙基-3-甲基苯胺基)丁酸甲酯的合成 |
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引用本文: | 丁成荣,李伟华,魏一凡,程延钊,张国富. 4-(N-乙基-3-甲基苯胺基)丁酸甲酯的合成[J]. 合成化学, 2016, 24(6): 529-532. DOI: 10.15952/j.cnki.cjsc.1005-1511.2016.06.15248 |
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作者姓名: | 丁成荣 李伟华 魏一凡 程延钊 张国富 |
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作者单位: | 浙江工业大学 化学工程学院,浙江 杭州 310014 |
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摘 要: | 以γ-丁内酯为起始原料,经开环氯化和醇解反应合成4-氯丁酸甲酯(2); 2与N-乙基间甲苯胺经亲核取代反应合成了4-(N-乙基-3-甲基苯胺基)丁酸甲酯,纯度97.5%,总收率75.3%,其结构经1H NMR确证。
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关 键 词: | &gamma -丁内酯 4-氯丁酸甲酯 4-(N-乙基-3-甲基苯胺基)丁酸甲酯 合成 |
收稿时间: | 2015-06-23 |
Synthesis of 4-(N-ethyl-3-methylanilino) butanoic Acid Methyl Ester |
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Abstract: | 4-Chlorobutyric acid methyl ester ( 2 ) was prepared by ring-opening chlorination, alcohol reaction, using 1,4-butyrolactone as the starting material. 4-( N-ethyl-3-methylanilino) butanoic acid methyl ester in total yield of 75 . 3% with purity of 97 . 5% was synthesized by nucleophilic substitution of 2 with N-ethyl-m-toluidine. The structure was confirmed by 1 H NMR. |
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Keywords: | 1,4-butyrolactone 4-chlorobutyric acid methyl ester 4-(N-ethyl-3-methylanilino)butano-ic acid methyl ester synthesis |
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