| 蒙脱土负载碘催化合成双吲哚甲烷衍生物 |
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| 引用本文： | 吴小云,尹晓刚,龚维,王野,陈卓. 蒙脱土负载碘催化合成双吲哚甲烷衍生物[J]. 合成化学, 2016, 0(11): 959-962. DOI: 10.15952/j.cnki.cjsc.1005-1511.2016.11.16164 |
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| 作者姓名： | 吴小云 尹晓刚 龚维 王野 陈卓 |
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| 作者单位： | 贵州师范大学 化学与材料科学学院 贵州省功能材料化学重点实验室,贵州 贵阳,550001 |
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| 基金项目： | 国家自然科学基金资助项目(21362006)，贵州省科技创新人才团队建设项目(黔科合人才团队[2014]4006号)，贵州省科技合作项目(黔科合LH字[2016]7218号)，贵州省科技厅科技支撑项目(黔科合支撑[2016]2311) |
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| 摘 要： | 以蒙脱土负载碘(MMT/I2)作催化剂,醛(1a~1g)与吲哚(2)反应合成双吲哚甲烷衍生物(3a~3g),其结构经1H NMR和IR确证。以3a的合成为例,研究了催化剂、溶剂、反应时间、温度和物料比r[n(1)∶n(2)]对3产率的影响。结果表明:在最佳合成条件(2 1 mmol,r=1.1∶2.0,10 mol%MMT/I2,乙腈1 m L,于25℃反应5min)下,3a~3g产率67.9%~96.2%。MMT/I2循环使用3次,3a产率78.6%。
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| 关 键 词： | 蒙脱土负载碘 催化 双吲哚甲烷衍生物 合成 |
Synthesis of Bis( indolyl) alkane Derivatives Catalyzed By I2 loaded Montmorillonite |
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| Abstract: | A series of bis(indolyl)alkane derivatives(3a~3g) were synthesized by the reaction of al-dehydes(1a~1g) with indole(2), using I2 loaded montmorillonite(MMT/I2) as catalyst. The struc-tures were confirmed by 1 H NMR and IR. Effects of catalyst, solvent, reaction time, reaction tempera-ture and mole ratio r[n(1) :n(2)] were investigated, using synthesis of 3a as the template reaction. The yields of 3a~3g were 67. 9% ~96. 2% under the optimum conditions(21 mmol, r=1. 1 :2. 0, 10 mol%MMT/I2 , acetonitrile 1 mL, reaction at 25 ℃ for 5 min). The yield of 3a was 78. 6% after MMT/I2 recycle for three times. |
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| Keywords: | loaded montmorillonite I2 catalysis bis( indolyl) alkane derivative synthesis |
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