手性Ru复合物催化剂的固载化及其不对称氢转移反应催化应用

Chiral Ru-BsDPEN, (1R,2R)-N-p-benzenesulfonyl-1,2-diphenylethylenediamine, catalyst has been immobilized on a mesoporous molecular sieve of MCM-41 type successfully. A hybrid mesoporous molecular sieve was synthesized using a precursor bearing benzene group, which in organosilica were sulfonylated and reacted with (1R,2R)-l,2-diphenylethylenediamine and RuC1E(p-cymene)]2 successively to afford immobilized catalyst. The Brunauer-Emmett-Teller (BET) surface area and Barrett-Joyner-Halenda (BJH) pore size decreased after immobilization of catalyst onto the mesoporous material. Enantioselective transfer hydrogenation of ketones catalyzed by immobilized catalyst showed the highest yield of 22.36% and e.e. value of 31.47% by using acetophenone as substrate when reaction time was 48 and 16 h respectively.

Immobilization of Chiral Ruthenium(II) Complex and Its Catalytic Application in Enantioselective Transfer Hydrogenation

Chiral Ru‐BsDPEN, (1R,2R)‐N,p‐benzenesulfonyl‐1,2‐diphenylethylenediamine, catalyst has been immobilized on a mesoporous molecular sieve of MCM‐41 type successfully. A hybrid mesoporous molecular sieve was synthesized using a precursor bearing benzene group, which in organosilica were sulfonylated and reacted with (1R,2R)‐1,2‐diphenylethylenediamine and RuCl₂(p‐cymene)]₂ successively to afford immobilized catalyst. The Brunauer‐Emmett‐Teller (BET) surface area and Barrett‐Joyner‐Halenda (BJH) pore size decreased after immobilization of catalyst onto the mesoporous material. Enantioselective transfer hydrogenation of ketones catalyzed by immobilized catalyst showed the highest yield of 22.36% and e.e. value of 31.47% by using acetophenone as substrate when reaction time was 48 and 16 h respectively.