Synthesis of Berberine-Efflux Pump Inhibitor Hybrid Antibacterials |
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| Authors: | Bremner John B Kelso Michael J |
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| Affiliation: | School of Chemistry, University of Wollongong, NSW 2522, Australia. |
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| Abstract: | This paper reports the compact synthesis of two isomeric dual-action hybrid antimicrobials where the 13-position of the antibacterial berberine has been linked via 3'- and 4'-methylene bridges to INF55 (5-nitro-2-phenylindole), an inhibitor of the bacterial NorA multidrug-resistance pump. |
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