Automated threshold detection for auditory brainstem responses: comparison with visual estimation in a stem cell transplantation study |
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Authors: | Sofie Bogaerts John D Clements Jeremy M Sullivan Sharon Oleskevich |
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Institution: | (1) Neuroscience Research Program, Garvan Institute of Medical Research, 2010 Sydney, Australia;(2) Faculty of Medicine, University of New South Wales, Sydney, Australia |
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Abstract: | Background Auditory brainstem responses (ABRs) are used to study auditory acuity in animal-based medical research. ABRs are evoked by
acoustic stimuli, and consist of an electrical signal resulting from summated activity in the auditory nerve and brainstem
nuclei. ABR analysis determines the sound intensity at which a neural response first appears (hearing threshold). Traditionally,
threshold has been assessed by visual estimation of a series of ABRs evoked by different sound intensities. Here we develop
an automated threshold detection method that eliminates the variability and subjectivity associated with visual estimation. |
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