A novel lignan glycoside with antioxidant activity from Tinospora sagittata var. yunnanensis |
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| Authors: | Huang Xiang-Zhong Cheng Chun-Mei Dai Yun Fu Guang-Miao Guo Jun-Ming Liang Hui Wang Chao |
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| Affiliation: | a Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission and Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities , Kunming 650031 , China. |
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| Abstract: | A novel lignan glysocide, namely sagitiside A (1), together with two known ones, (+)-lyoniresinol-2α-O-β-D-glucopyranoside (2) and (+)-5'-methoxyisolariciresinol 3α-O-β-D-glucopyranoside (3), was isolated from the 95% ethanol extract of dry roots of Tinospora sagittata var. yunnanensis. The structure of the new compound (1) was determined based on MS, 1D and 2D NMR spectral data. Compounds 1-3 showed antioxidant activity with EC(50) values 55, 75 and 80?μM by 1,1-diphenyl-2-picryhydrazyl (DPPH) radical-scavenging assay. |
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