Quinoline derivatives: potential antiparasitic and antiviral agents

The crystal structures of closely related quinoline compounds substituted at the 2‐position by a vinyl group, either including a Cl atom 2‐(1‐chloro‐2‐methylprop‐1‐enyl)‐8‐nitroquinoline, C₁₃H₁₁ClN₂O₂, (I)] or not 2‐(2‐methylprop‐1‐enyl)‐8‐nitroquinoline, C₁₃H₁₂N₂O₂, (II)], show an important deviation of the vinyl group from coplanarity with the quinoline ring system if the Cl atom is present. The nitro group is perpendicular in (II)] or nearly so in (I)] to the quinoline ring system. In (II), all non‐H atoms except the nitro O atoms are located on a crystallographic mirror plane.