Copper-catalyzed oxidative direct cyclization of N-methylanilines with electron-deficient alkenes using molecular oxygen |
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Authors: | Nishino Mayuko Hirano Koji Satoh Tetsuya Miura Masahiro |
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Institution: | Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan. |
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Abstract: | The oxidative direct cyclizaion of N-methylanilines with electron-deficient alkenes involving maleimides and benzylidene malononitriles through sp(3) and sp(2) C-H bond cleavage proceeds effectively under a CuCl(2)/O(2) catalysis to provide the corresponding tetrahydroquinolines in good yields. |
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