Molecularly imprinted polymers: modulating molecular recognition by a thermal phase transition in the binding framework |
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Authors: | Songjun Li Xing Huang Mingxia Zheng Wuke Li |
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Affiliation: | Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079, China. Lsjchem@yahoo.com.cn |
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Abstract: | The concept used to realize the modulation of molecular recognition in a molecularly imprinted polymer is presented. Creating a thermal phase transition within the binding framework, the imprinted material was prepared using Boc-phenylalanine as the template and pNIPAM as the sensitive unit. The results indicate that such a transition causes a clear modulation in the recognition behavior of the prepared polymer which depends on the operation temperature. At a relatively low temperature, the prepared polymer acts like a traditionally imprinted one, showing a highly specific recognition for the imprint species. However, the prepared polymer does not present any notable resolution at 40 degrees C. This recognition behavior is comparable to a process that can be switched on and off, thus making modulated recognition feasible. |
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