Total synthesis of (+/-)-8alpha-hydroxystreptazolone |
| |
Authors: | Nomura Izumi Mukai Chisato |
| |
Institution: | Faculty of Pharmaceutical Sciences, Kanazawa University, Takara-machi, Kanazawa 920-0934, Japan. |
| |
Abstract: | reaction: see text] The intramolecular Pauson-Khand reaction of 2-oxazolone derivatives with a suitable pentynyl appendage exclusively gave the corresponding 4-hydroxy-6-substituted-9-oxa-1-azatricyclo6.2.1.0(5,11)]undec-5-en-7,10-diones. Based on this newly developed Pauson-Khand reaction of 2-oxazolone-alkyne derivatives, the first total synthesis of (+/-)-8alpha-hydroxystreptazolone was accomplished in a highly stereoselective manner. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|