有机合成中的高价碘应用

高价碘化物作为一种性能温和、选择性强及环境友好的氧化试剂在有机合成中得到了广泛的应用。近年来,各种不同结构的高价碘试剂和各种新的反应及应用大量涌现出来,使它们的应用领域从传统的醇类氧化扩展到一些结构复杂化合物的合成领域当中。本文以最常用和研究较多的几个高价碘化合物为例,对它们用于有机合成反应,如氧化、加成、取代和重排的最新进展进行了概述,对本研究小组重点研究的五价碘化合物邻羟基苯碘酰与酮类化合物的取代反应和烯烃化合物的加成反应也作了介绍。

Hypervalent Iodine Compounds in Organic Synthesis

As a kind of mild,high selective and environment-friendly oxidation reagents,hypervalent iodine compounds have been widely applied in organic synthesis.In recent years,variety of hypervalent iodine compounds with new structure and new reactions and their applications massively emerged,which made their application extend from the traditional alcohol oxidation to the synthesis of some complex structure compounds.The recent progress of hypervalent iodine compounds in organic synthetic reactions,such as the oxidation,addition,substitution and rearrangement,is summarized via the common members of the hypervalent iodine compound family with references.Author's research focus which is mainly on the addition of ketones and the substitution reaction of alkenes with hypervalent iodine compound ortho-iodoxybenzoic acid are introduced.