Thermal study of some new quinolone ruthenium(III) complexes with potential cytostatic activity |
| |
Authors: | Mihaela Badea Rodica Olar Dana Marinescu Valentina Uivarosi Teodor Octavian Nicolescu Daniela Iacob |
| |
Affiliation: | (1) Faculty of Chemistry, Department of Inorganic Chemistry, University of Bucharest, 90-92 Panduri Street, Sector 5, Bucharest, 050663, Romania;(2) Department of Inorganic Chemistry, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia Street, Bucharest, Romania |
| |
Abstract: | A series of new complexes with mixed ligands of the type RuL m (DMSO) n Cl3·xH2O ((1) L: oxolinic acid (oxo), m = 1, n = 0, x = 4; (2) L: pipemidic acid (pip), m = 2, n = 1, x = 2; (3) L: enoxacin (enx), m = 2, n = 1, x = 0; (4) L: levofloxacin (levofx), m = 2, n = 2, x = 8; DMSO: dimethylsulfoxide) were synthesized and characterized by chemical analysis, IR and electronic data. Except oxolinic acid that behaves as bidentate, the other ligands (quinolone derivatives and DMSO) act as unidentate. Electronic spectra are in accordance with an octahedral stereochemistry. The thermal analysis (TG, DTA) in synthetic air flow elucidated the composition and also the number and nature of both water and DMSO molecules. The TG curves show 3–5 well-separated thermal steps. The first corresponds to the water and/or DMSO loss at lower temperatures followed either by quinolone thermal decomposition or pyrolisys at higher temperatures. The final product is ruthenium(IV) oxide. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|