Correlations of the rate constants of phosphorylation reactions with the empirical parameters of the solvent polarity |
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Authors: | V E Bel'skii |
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Institution: | (1) A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan' Research Center of the Russian Academy of Sciences, 8 ul. Akad. Arbuzova, 420083 Kazan, Russian Federation |
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Abstract: | Regression analysis of the solvent effects on the rate constants of nucleophilic substitution at the phosphoryl group was
performed with the use of the empirical parameters of solvent polarity which characterize the ability of the solvents to electrophilic
and nucleophilic solvation. The nucleophilic solvation of reagents by solvents, as a rule, favors the phosphorylation reactions.
In the phosphorylation reactions of anionic nucleophiles, the electrophilic solvation of anions influences negatively the
reactions rates. The phosphorylation of amines by chlorides of phosphorus acids is facilitated by the electrophilic solvation
of a separated anion.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 271–274, February, 1998. |
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Keywords: | phosphorylation reactions solvent effects rate constants regression analysis |
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