A facile synthesis and the asymmetric catalytic activity of BINOL-based thiazole (thiadiazole) thioether ligands |
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| Authors: | Zhi-Bing Dong |
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| Affiliation: | State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, PR China |
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| Abstract: | Four new BINOL-based thiazole (thiadiazole) thioether ligands (S)-1, (S)-2, (S,S)-3 and (S)-4 were prepared. When their catalytic effectiveness was tested, good results (up to 93% ee and 97% yield) were obtained in the asymmetric addition of diethylzinc to aldehydes while poor results were obtained in the asymmetric conjugate addition of diethylzinc to enones. |
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| Keywords: | BINOL Diethylzinc Titanium tetraisopropoxide Copper trifluoromethanesulfonate Asymmetric addition |
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