Optical properties of normal and thermally coagulated chicken liver tissue measured ex-vivo with diffuse reflectance |
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Authors: | Hafeez-Ullah Atif M Firdous S Mehmood M S Hamza M Y Imran M Hussain G Ikram M |
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Institution: | 1.Department of Physics and Applied Mathematics, Pakistan Institute of Engineering and Applied Sciences, Islamabad, 45650, Pakistan ;2.National Institute of Lasers and Optronics, Islamabad, 45650, Pakistan ;3.Department of Physics, University of Memphis, Memphis, Tennessee, USA ; |
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Abstract: | The purpose of the present study is to determine the optical properties of normal and thermally coagulated chicken liver at
720, 740, 770, 810, 825 and 840 nm wavelengths of laser irradiation. So, we were able to evaluate these optical properties
(absorption and scattering coefficients) with ex-vivo study using Kubelka Munk Model (KMM) from the radial dependence of the diffuse reflectance with femtosecond pulsed laser
in near IR region. These coefficients were significantly increased with coagulation. The penetration depths of the diffused
light have been reported to a maximum value of 8.12 ± 0.36 mm in normal liver and 2.49 ± 0.17 mm in coagulated liver at 840
nm showing increasing behavior towards IR region. The Monte Carlo simulation was used to check the theoretical validation
of measured optical properties of the tissue that showed a good match with our experimental results. We believe that these
differences in optical properties will be helpful for the understanding arid optimal use of laser applications in medicine
and differential diagnosis of tissues by using different optical methods. Especially for the investigation of biological tissue
for photodynamic therapy (PDT), the knowledge of the specific optical properties and their thermo-induced changes is important. |
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