Studies on the reactivity of 3-methyl-4-nitro-5-styrylisoxazoles with S-nucleophiles |
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| Authors: | Simone BruschiMaria Moccia Mauro FA Adamo |
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| Institution: | Centre for Synthesis and Chemical Biology (CSCB), Department of Pharmaceutical and Medicinal Chemistry, The Royal College of Surgeons in Ireland, 123 St. Stephen’s Green, Dublin 2, Ireland |
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| Abstract: | We have investigated the reactivity of 3-methyl-4-nitro-5-styrylisoxazoles with S-nucleophiles. This study revealed that the title compounds were optimal Michael acceptors toward thiols. A procedure was also established to prepare isoxazole-containing sulfides in one-pot and without the use of chromatography. Isoxazole-containing sulfides were converted into the corresponding sulfones in high yield. |
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| Keywords: | Multicomponent synthesis Polyfunctional scaffolds 4-Nitroisoxazoles |
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