Copper catalysed domino decarboxylative cross coupling-cyclisation reactions: synthesis of 2-arylindoles |
| |
| Authors: | Thanasekaran Ponpandian Shanmugam Muthusubramanian |
| |
| Institution: | a Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625021, India
b Orchid Chemicals and Pharmaceuticals Ltd, Department of Medicinal Chemistry, R&D Centre, Chennai 600119, India |
| |
| Abstract: | The efficient synthesis of 2-arylindoles and 6H-isoindolo2,1-a]indol-6-one through copper catalysed domino sp-sp2 decarboxylative cross-coupling and subsequent cyclisation reactions of arylpropiolic acids with 2-iodotrifluoroacetanilide has been described. This methodology also demonstrates that indolo1,2-c]quinazolin-6(5H)-one can be obtained with the elimination of trifluoromethyl anion. |
| |
| Keywords: | 2-Alkynoic acid 2-Iodotrifluoroacetanilide Decarboxylative cross-coupling Domino reaction Copper mediated reactions |
| 本文献已被 ScienceDirect 等数据库收录！ |
