One-pot synthesis of thieno [2,3-d] pyrimidin-4-ol derivatives mediated by polyphosphonic anhydride |
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| Authors: | Subba PoojariP. Parameswar Naik G. Krishnamurthy |
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| Affiliation: | a Syngene International Ltd, Biocon Park, Plot Nos. 2 & 3, Bommasandra IV Phase, Jigani Link Road, Bangalore 560 099, India
b Department of P.G. Studies and Research in Chemistry, Sahadri Science College (Autonomous), Shimoga 577 203, India |
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| Abstract: | An efficient synthesis of thiopyrimidines with different substituents in position 2 is described. A rapid, mild and high yielding microwave-assisted one-pot cyclization of 5-substituted 2-amino thiophene-3-carboxamide derived from Gewald reaction1 with T3P and different acids gives the corresponding thiopyrimidines. The significant feature of this method includes less reaction time, high purity and reduced toxicity of the reaction. |
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| Keywords: | Thiopyrimidines Propylphosphonic anhydride Microwave initiator Heteroaromatic |
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