Zinc(II) and PPi selective fluorescence OFF-ON-OFF functionality of a chemosensor in physiological conditions |
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Authors: | Ravikumar I Ghosh Pradyut |
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Institution: | Department of Inorganic Chemistry, Indian Association for the Cultivation of Science (IACS), 2A and 2B Raja S. C. Mullick Road, Kolkata 700032, India. |
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Abstract: | A fluorescent chemosensor based on a quinoline derivative, L(2) (OFF state), selectively senses Zn(2+) by effective chelate-enhanced fluorescence (ON state), which further shows selectivity toward PPi over competing anions like Pi, AMP, and ATP via fluorescence quenching (OFF state) in a 100% aqueous HEPES buffer (pH 7.4). A plausible mode for the selective binding of PPi to 1 has been demonstrated by quantum mechanical density functional theory calculations and high-resolution mass spectrometry analysis. |
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