Enhanced peptide beta-sheet affinity by metal to ligand coordination |
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| Authors: | Kruppa Michael Bonauer Christoph Michlová Veronika König Burkhard |
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| Institution: | Institut für Organische Chemie, Universit?t Regensburg, Universit?tsstrasse 31, D-93040 Regensburg, Germany. |
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| Abstract: | A histidine-coordinating metal complex substituted with methoxypyrrole amino acids (MOPAS) as a peptide beta-sheet binder shows high affinity for a H(2)N-His-Leu-Leu-Val-Phe-OMe pentapeptide in DMSO solution. Within the complex, a beta-sheet conformation is induced into the pentapeptide by weak intra-assembly interactions with the MOPAS units. |
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