分子印迹液相色谱整体柱

分子印迹是合成预定选择性固定相的新兴技术，整体柱是新型的色谱固定相技术。将分子印迹聚合物与整体柱技术相结合，可以有效提高液相色谱的分离效率，有助于推动整个分离科学的发展，意义重大，是当今分析化学的研究热点。本文就分子印迹液相色谱整体柱的制备合成、色谱分离条件以及物理化学特性评价方法等方面的研究进展进行了较系统的综述，并对该技术目前存在的问题和发展前景进行了探讨。

Monolithic Column for High Performance Liquid Chromatography

Molecular imprinting is a new approach to prepare predictable selectivity stationary and monolithic collumn is a novel technology for chromatographic stationary phase. The combination of monolith and molecularly imprinted polymers(MIPs) integrates the high efficiency of liquid chromatography and the high selectivity of MIPs, which will accelerates the develpoment of MIPs technique in the field of separation science. Therefore, the research in this field has attracted considerable interests and plays an important role in the area of analytical chemistry. In this review，the progress of molecularly imprinted monolith is summarized in detail from the polymerization conditionsto prepare MIPs' physical monolith, the separation conditions to evaluate the efficiency of MIPs, and the method of characterizingg MIPs' physical and chemical properties concerning the application of liquid chromatography-based MIPs. The limitations and prospective applications of the technique relates with MIPs monolithic column are also discussed．