| 脂质体毛细管电泳方法评价有机化合物在体内的吸收 |
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| 引用本文： | 邹小兵,蒋宏贵,董志强,夏之宁,蒋雪梅.脂质体毛细管电泳方法评价有机化合物在体内的吸收[J].色谱,2008,26(6):672-676. |
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| 作者姓名： | 邹小兵 蒋宏贵 董志强 夏之宁 蒋雪梅 |
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| 作者单位： | 1.Department of Pharmaceutics, Institute of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400030, China; 2.College of Bioengineering, Chongqing University, Chongqing 400030, Chin |
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| 基金项目： | 国家自然科学基金
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科技部国际科技合作项目
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| 摘 要： | 有机化合物在脂质体毛细管电泳中的保留值大小可以体现化合物的亲脂性大小。比较了9种有机化合物在脂质体毛细管电泳中脂质体/水的疏水参数(log Plw)(由保留因子k的对数值(log k)转化而来)及其在正辛醇/水体系中的疏水参数(log Pow)与其渗透系数的对数值(log Pm)的相关性，log Plw与log Pm的相关系数为0.94,log Pow与log Pm的相关系数仅为0.78,说明脂质体/水模型较正辛醇/水模型更加接近于生物膜模型。脂质体毛细管电泳可以快速、准确地测定化合物的疏水参数,通过化合物在脂质体毛细管中的保留可以快速、初步地预测化合物在体内的吸收情况。
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| 关 键 词： | 渗透系数 疏水参数 体内吸收 有机化合物 预测 脂质体毛细管电泳 |
| 收稿时间： | 2008-4-23 |
| 修稿时间： | 2008-7-1 |
Evaluation of absorption of organic compounds in human body using liposome capillary electrophoresis |
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| ZOU Xiaobing,JIANG Honggui,DONG Zhiqiang,XIA Zhining,JIANG Xuemei.Evaluation of absorption of organic compounds in human body using liposome capillary electrophoresis[J].Chinese Journal of Chromatography,2008,26(6):672-676. |
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| Authors: | ZOU Xiaobing JIANG Honggui DONG Zhiqiang XIA Zhining JIANG Xuemei |
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| Institution: | 1.Department of Pharmaceutics, Institute of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400030, China; 2.College of Bioengineering, Chongqing University, Chongqing 400030, Chin |
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| Abstract: | Liposome capillary electrophoresis (LCE) was used as a model for the in vitro evaluation of the degree of membrane penetration of organic compounds. The hydrophobic parameters of 9 compounds were determined by LCE. In comparison of the correlation coefficient of log Plw ( the logarithm of the partition coefficient of liposome/water system, calculated from retention factor) vs. log Pm (the logarithm of osmotic coefficient) with that of log Pow (the logarithm of the partition coefficient of octanol/water system) vs. log Pm, the former was 0.94, much greater than the latter 0.78. It means that as the biomembrane model, liposome is more similar than the octanol/water system. The LCE method has the potential to be an in vitro screening model. |
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| Keywords: | liposome capillary electrophoresis hydrophobic parameter permeability coefficient absorption in human body organic compounds prediction |
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