Synthesis of Tri-And Tetrasaccharides Present in the Linkage Region of Heparin and Heparan Sulphate |
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| Authors: | Marianne Nilsson Jacob Westman Carl-Magnus Svahn |
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| Institution: | Organic Chemistry , Kabi Pharmacia AB , S-112 87, Stockholm, Sweden |
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| Abstract: | Abstract The methyl glycosides of the the tri-and tetrasaccharides present in the linkage region of heparin, methyl O-(β-D-galactopyranosyl)-(l→3)-O-(β-D-galactopyranosyl)-(l→4)-β-D-xylopyranoside and methyl O-(β-D-glucopyranosyluronic acid)-(l→3)-O-(β-D-galactopyranosyl)-(l→3)-O-(β-D-galactopyranosyl)-(l→4)-β-D-xylopyranoside sodium salt, were synthesized together with their phosphate containing analogues, methyl O-(β-D-galactopyranosyl)-(l→3)-O-(β-D-galactopyranosyl)-(l→4)-β-D-xylopyranoside 2-(disodium phosphate) and methyl O-(β-D-glucopyranosyluronic acid)-(l→3)-O-(β-D-galactopyrano-syl)-(l→3)-O-(β-D-galactopyranosyl)-(l→4)-β-D-xylopyranoside 2-(disodium phosphate) sodium salt, which are glycosides of the structure found in the linkage region of heparan sulphate. |
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