A Simple Synthesis of C-Glucosides Related to the Antitumor Agent Etoposide |
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| Authors: | Pietro Allevi Mario Anastasia Pierangela Ciuffreda Antonio Scala |
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| Institution: | Department of Chemistry and Biochemistry , University of Milan , Via Saldini 50, I-20133, Milan, Italy |
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| Abstract: | Abstract The synthesis of four new lignan derivatives 2a, 2b, 3a and 3b related to the anticancer agent etoposide has been accomplished. In these compounds a methylene or ethylene group of a C-glucoside separates the glucosidic moiety as present in etoposide (1) from its lignan aglycone bonded by an ethereal function. The key step in the synthesis involves the reaction of a benzylated alditol 4 or 5 and the unprotected 4′-demethylepipodophyllotoxin (6). |
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