Synthesis and Antiviral Evaluation of Some 5‐N‐Arylaminomethyl‐2‐glycosylsulphanyl‐1,3,4‐oxadiazoles and Their Analogs against Hepatitis A and Herpes Simplex Viruses |
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Authors: | Wael A El‐Sayed Nahed M Fathi W A Gad |
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Institution: | Photochemistry Department , National Research Centre , Cairo, Egypt |
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Abstract: | N‐Arylaminomethyl‐3H‐1,3,4‐oxadiazole‐2‐thiones 2a,b were prepared from the corresponding N‐arylglycinoylhydrazides. A number of their thioglycoside derivatives 4–7a–c and S‐functionalized analogs 8–11a,b were synthesized by the reaction with different acetobromosugars and acyclic hydroxyalkylating agents. The antiviral activity of a number of the synthesized compounds against herpes simplex virus type 1 (HSV‐1) and hepatitis A virus (HAV) was evaluated. Compounds 5a and 5b showed promising results against HAV. |
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Keywords: | Thioglycosides Oxadiazole S‐Functionalized‐oxadiazole Glycinoyl hydrazine Antiviral activity Herpes simplex virus type 1 (HSV‐1) Hepatitis A virus (HAV) |
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