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Synthesis and Antiviral Evaluation of Some 5‐N‐Arylaminomethyl‐2‐glycosylsulphanyl‐1,3,4‐oxadiazoles and Their Analogs against Hepatitis A and Herpes Simplex Viruses
Authors:Wael A El‐Sayed  Nahed M Fathi  W A Gad
Institution:Photochemistry Department , National Research Centre , Cairo, Egypt
Abstract:

N‐Arylaminomethyl‐3H‐1,3,4‐oxadiazole‐2‐thiones 2a,b were prepared from the corresponding N‐arylglycinoylhydrazides. A number of their thioglycoside derivatives 47ac and S‐functionalized analogs 811a,b were synthesized by the reaction with different acetobromosugars and acyclic hydroxyalkylating agents. The antiviral activity of a number of the synthesized compounds against herpes simplex virus type 1 (HSV‐1) and hepatitis A virus (HAV) was evaluated. Compounds 5a and 5b showed promising results against HAV.
Keywords:Thioglycosides  Oxadiazole  S‐Functionalized‐oxadiazole  Glycinoyl hydrazine  Antiviral activity  Herpes simplex virus type 1 (HSV‐1)  Hepatitis A virus (HAV)
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