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Synthesis and Preliminary Evaluation of 2-Chloroethylnitrosourea Derivatives of Sucrose |
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| Authors: | Tetsuo Suami Tsuguhiro Kato Kazuaki Kanai Shuichi Ohki Hideyo Yamashita |
| Institution: | 1. Department of Applied Chemistry Faculty of Science and Technology , Keio University , Hiyoshi, Yokohama, 223, Japan;2. The Nissin Sugar Manufacturing Co. Ltd. , Toyosu, Koto-ku, Tokyo, 135, Japan |
| Abstract: | Abstract 2-Chloroethylnitrosourea derivatives of sucrose have been synthesized as potential antineoplastic agents. Two compounds: 6-(2-chloroethyl)nitrosoamino]carbonyl]amino]-6-deoxysucrose and 6′-(2-chloroethyl)nitrosoamino]carbonyl]amino]-6′-deoxysucrose exhibited significant antitumor activity against experimental leukemia L1210 in mice. Their chemical decomposition rates (T0.5) have been determined. |
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