Reductive Amination of the Lysine N ε-Amino Group Leads to a Bivalent Glyco-Amino Acid Building Block Suited for SPPS |
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| Authors: | Alexander Schierholt Thisbe K Lindhorst |
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| Institution: | Otto Diels Institute of Organic Chemistry, Christiana Albertina University of Kiel , Otto-Hahn-Platz 4, D-24098, Kiel, Germany |
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| Abstract: | Aiming at the synthesis of structurally altered glycopeptides to probe multivalency effects in carbohydrate recognition, a glyco-amino acid building block was prepared, carrying a bivalent carbohydrate branching unit. This new mannosylated lysine derivative was shown to be fully suitable for solid-phase peptide synthesis. |
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| Keywords: | Glyco-amino acids Reductive amination Glycopeptides Solid-phase synthesis |
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